*,
*::before,
*::after {
  box-sizing: border-box;
}

* {
  -webkit-user-select: none;
  /* Safari */
  /* IE 10 and IE 11 */
  -moz-user-select: none;
  user-select: none;
  /* Standard syntax */
}

body {
  margin: 0;
  padding: 0;
}

:root {
  --largura: 600px;
  --tituloFontsize: 25px;
  --largTabela: 500px;
  --larguraSlider: 400px;
  --alturaSlider: 4px;
  --fontearange: 15px;
  --referenciaFontsize: 16px;
  --areferenciaFontsize: 15px;
}

.container {
  position: relative;
  width: var(--largura);
  display: grid;
  grid-template-columns: auto;
  grid-template-rows: auto;
  margin-left: auto;
  margin-right: auto;
}

.titulo {
  padding: 15px 0px 5px 0px;
  font-size: var(--tituloFontsize);
  text-align: center;
}

.subt {
  font-size: var(--subtituloFontsize);
  text-align: center;
}

.rotas {
  display: grid;
  grid-template-columns: auto;
  grid-template-rows: auto auto auto;
  justify-content: end;
  margin-bottom: 3px;
  margin-right: 3px;
}

.lang a {
  padding: 3px 12px 3px 12px;
  text-decoration: none;
  background-color: black;
  color: white;
  font-size: 11px;
  border-radius: 5px;
  margin-right: 3px;
}

.item {
  background-color: #9eecef;
  border-bottom: 2px solid rgb(194, 240, 249);
  overflow: hidden;
}

.from {
  display: grid;
  grid-template-columns: auto;
  grid-template-rows: auto auto auto;
  align-items: center;
  justify-items: center;
  row-gap: 5px;
  margin-top: 10px;
}

.botao {
  font-family: Georgia, "Times New Roman", Times, serif;
  font-size: 14px;
  padding: 2px 0px 2px 0px;
  border-radius: 6px;
  margin-left: 5px;
}

.textoBotao {
  text-align: center;
}

.ui-menu-item {
  font-family: Georgia, "Times New Roman", Times, serif;
  font-size: 14px;
  text-align: center;
}

#dose {
  width: 60px;
  margin-left: 5px;
  text-align: center;
}

.doslider {
  margin-top: 0px;
  margin-bottom: 10px;
}

.slider {
  -webkit-appearance: none;
  -moz-appearance: none;
       appearance: none;
  width: var(--larguraSlider);
  height: var(--alturaSlider);
  border-radius: 2px;
  background: blue;
  outline: none;
  transition: opacity 0.2s;
}

.slider::-webkit-slider-thumb {
  -webkit-appearance: none;
  appearance: none;
  width: 20px;
  height: 20px;
  border-radius: 50%;
  background: #4CAF50;
  cursor: pointer;
}

.osopioides {
  display: flex;
  flex-direction: row;
  align-items: center;
  justify-content: center;
  margin-bottom: 5px;
}

.omenu {
  max-height: 150px;
  overflow-y: auto;
}

.atabela {
  width: var(--largTabela);
  margin-left: auto;
  margin-right: auto;
  background-color: white;
  margin-top: 10px;
  margin-bottom: 10px;
}

.tabOpioides {
  width: 100%;
  border-collapse: collapse;
  text-align: center;
}

.tabOpioides tr,
.tabOpioides td,
.tabOpioides th {
  border: 1px solid black;
  padding: 5px;
}

.tabOpioides td:first-child {
  font-size: 16px;
}

.oresult {
  font-size: var(--fontearange);
  font-weight: bold;
}

.arange {
  font-size: var(--fontearange);
  font-weight: bold;
}

.referencia,
.areferencia {
  padding: 2px 5px 4px 20px;
  text-indent: -15px;
  font-size: var(--referenciaFontsize);
  font-weight: bold;
}

.referencia {
  font-style: italic;
  text-decoration: underline;
}

.areferencia {
  font-size: var(--areferenciaFontsize);
  font-weight: normal;
}

@media screen and (max-width: 480px) {
  :root {
    --largura: 100%;
    --tituloFontsize: 20px;
    --largTabela: 96%;
    --larguraSlider: 300px;
    --alturaSlider: 3px;
    --fontearange: 12px;
    --referenciaFontsize: 13px;
    --areferenciaFontsize: 12px;
  }
}